• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Pankreatin-Pellets werden erfindungsgemäß dadurch hergestellt, daß man aus Pankreatin-Pulver und einem enzymfreundlichen Lösungsmittel eine verformbare Masse herstellt, diese auf einer Strangpresse, ggf. unter Kühlung, extrudiert, in Strangschnittlinge zerteilt, trocknet und nach an sich bekannten Methoden weiterverarbeitet. Die so erhaltenen Pankreatin-Pellets werden in Arzneimitteln verwendet.
    公开号:SU1256690A3
    申请号:SU802911402
    申请日:1980-04-21
    公开日:1986-09-07
    发明作者:Вишниевски Мартин；Файхо Лутц；Фишер Герхард；Пешке Гюнтер
    申请人:Кали-Хеми Фарма Гмбх (Фирма)；
    IPC主号:
    专利说明:

    This invention relates to medicine, in particular, to a method for producing granulated nancreatin.
    The aim of the invention is to increase the content of pancreatin in the granule.
    Example 1. In a laboratory mixer, mix 4AOO g of pancreatin with manganese stearate and add 400 ml of acetone to moisten. The mixture is pressed on a screw press with holes of 1, 6 mm in diameter and then cut into pieces with a length of up to 5.7 mm.
    After drying, the cylindrical raw material.-Granules in a plating drum are spherical in shape by alternately applying nacrythine and a solution of polyphenylpyrrolide (Kollidon K 25) in acetone. This requires 1 l of rast73or and 300 g of pancreatin,
    Round granules are smoothed by applying a solution of 50 g of polyethylene glycol 6000 in 100 liters of acetone.
    After drying, the granules are coated with a GATT-WSGS5 layer resistant to gastric juice and applied to a device with a fluidizing system and a layer of GLATT-WSGS5 type. For 6.3 kg of pancreatin granules, 7,200 g of a solution of 590 g of oxypropyl phthalate, gp1; elt, tyuz (IIP55 m, manufactured by Yinestsu, Japan) and 150 g of dibutyl phthalate, and both of 3230 g of methylene chloride and isopropanol, are required.
    Yield of 7000 g of granules resistant to gastric juice with a diameter of 1.6-2.0 mm and 86% nancreatin content
    For example, 2, 4AOO and g of Pakreatin are mixed in a laboratory mixer with 150 g of magnesium steg and about 100 ml of isopropanol is added to moisten. The mixture is pressed on a screw press with holes of 1.6 m in diameter and then cut into pieces with a length of 1. 5 - 1, 1 mm.
    After drying, the folded material of the cylindrical form is rounded, giving it a spherical shape by alternately applying a 1% isopropanol solution of POLYIIIL-pyrroleidopa (Kollidon K 25) and pancreatin, -This requires about 1 l of solution and 800 g of pancreatia.
    Round granules are added in a drum, smoothness with application of 50 g of polyethylene glycol 6000 and 00 ml of isonronanol,
    s 0
    50,
    five
    five
    0
    0
    After drying, a gastric juice-resistant coating was applied to the granules in a glatt-pseudo-augmented bedding unit (WSGS-5). To obtain 6.3 kg of pancreatic granules, 7200 g of a solution consisting of 590 g of hydroxynroPylcellulose phthalate (type HP 55, manufactured by SHLNETSU, Japan) and 150 g of dibutyl phthalate for every 3230 g of methyl chloride and isopropanol are required.
    The yield of about 7000 g resistant to the effects of gastric juice granules with a diameter of 1.6 - 2 mm and a pancreatin content of about 86%.
    Example 3. 4400 g of pakreatin are coated in a laboratory mixer with a mixture of 400 ml of isopropanol and I of 200 g of sym.-tetrafluorodichloroethane (caltron 114, manufacturer. Cali-Chemie AG).
    The mixture is pressed on a screw press with holes of 1.6 mm in diameter and then cut into pieces.
    After drying, the cylindrical granules are given a spherical shape in the coating drum by alternately applying 1% polyvinylpyrrolidone solution (Kollidon K 25) and Pancreatin. This requires about 1 l of solution and 1800 g of pakreatin,
    Round into granules is polished by applying a solution of 30 g of Kollidon K 25 in 1QO ml of isopropanol.
    After drying, the granules are coated in a glatt fluid bed (WSGS-5) with a coating resistant to gastric juice. To obtain 6.2 kg of preatatin granules, 7000 g of solution from 590 g of hydroxypropylcellulose phthalate (type HP 55) and 150 g of dibutyl phthalate per 3230 g of methylene chloride and isonropanol are required.
    The yield of about 6800 g resistant to the action of gastric juice granules with pancreatic content: about 89%. ,
    In another embodiment of the method, the rounding is carried out as follows
    250 g of polyethylene glycol 6000 is dissolved at 40-50 ° C in 3.5 g of acetone; 150 g of pancreatin are dispersed in a warm solution in a powder. This suspension is applied in several stages in a coating pan to also heated to 40 ° C untreated312566904
    all granules (5000 g). The contents of the granules, which, without the boiler afterwards, are processed until drying is easy to handle and it is not cooled to room temperature, which can be applied to other coatings. In this way, rounds are obtained.
    权利要求:
    Claims (1)
    [1]
    METHOD FOR PRODUCING GRANULATED PANCREATIN, including mixing pacreatin with excipients, moistening with acetone, subsequent removal of the solvent and coating the resulting granules with a film insoluble in gastric juice, characterized in that, in order to increase the pancreatin content in the granules, isopropanol or its mixture with 33 vol.% liquid hydrocarbon chlorofluoride, while the ratio of pancreatin and solvent is 14.3: (1-3), the resulting mixture is extruded on a worm press, section ayut apart at a ratio of diameter and length of 1: 1 and after removal of the solvent added pancreatin powder and the granules give spherical shape.
    СО с бе сл 05 05 с ©> cm
    类似技术:
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    同族专利:
    公开号 | 公开日
    AT6030T|1984-02-15|
    EP0021129B1|1984-02-01|
    IL59893D0|1980-06-30|
    IE49584B1|1985-10-30|
    DE3066366D1|1984-03-08|
    EP0021129A2|1981-01-07|
    NO158949B|1988-08-08|
    FI84022C|1991-10-10|
    ES489967A1|1980-10-01|
    GR69290B|1982-05-13|
    AR228427A1|1983-03-15|
    EP0021129A3|1981-11-11|
    DK244480A|1980-12-09|
    EP0021129B2|1988-09-07|
    US4280971A|1981-07-28|
    NO158949C|1988-11-16|
    IE800733L|1980-12-08|
    KR850000625B1|1985-05-06|
    PT71136A|1980-05-01|
    AU5755280A|1981-10-15|
    KR830002513A|1983-05-30|
    DE2923279C2|1987-07-09|
    IL59893A|1983-03-31|
    CA1142082A|1983-03-01|
    NO801690L|1980-12-09|
    NZ193476A|1982-11-23|
    DK158932B|1990-08-06|
    JPS55164622A|1980-12-22|
    FI84022B|1991-06-28|
    ZA802919B|1981-05-27|
    DK158932C|1991-01-21|
    FI801779A|1980-12-09|
    JPH0428691B2|1992-05-15|
    AU532838B2|1983-10-13|
    DE2923279B1|1980-11-20|
    DD151184A5|1981-10-08|
    PH16898A|1984-04-05|
    引用文献:
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    GB1342409A|1970-07-23|1974-01-03|Ciba Geigy Ag|Flowable pancreatin preparation of low microorgan ism content and a process for its manufacture|
    BE795766A|1972-02-22|1973-08-22|Lilly Co Eli|PROPOXYPHENE DELAY NAPSYLATE PARTICLES AND PROCESS FOR MANUFACTURING SUCH PARTICLES|
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    GB1509866A|1975-06-10|1978-05-04|Johnson & Johnson|Enteric coated digestive enzyme compositions|
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    DE3721574A1|1987-06-30|1989-01-12|Kettelhack Riker Pharma Gmbh|MEDICINAL PRODUCTS IN THE FORM OF PELLETS WITH ENZYMATICALLY CONTROLLED DRUG RELEASE|
    US4944944A|1987-11-19|1990-07-31|Oklahoma Medical Research Foundation|Dietary compositions and methods using bile salt-activated lipase|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    DE2923279A|DE2923279C2|1979-06-08|1979-06-08|LV920118A| LV5010A3|1979-06-08|1992-09-15|Method of obtaining granuleta pancreatin|
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